Blar i forfatter "Wappner, Pablo"

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    • The immunophilin Zonda controls regulated exocytosis in endocrine and exocrine tissues 

      de la Riva-Carrasco, Rocío; Perez-Pandolfo, Sebastián; Suárez Freire, Sofía; Romero, Nuria M.; Bhujabal, Zambarlal; Johansen, Terje; Wappner, Pablo; Melani, Mariana (Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-18)
      Exocytosis is a fundamental process in physiology, that ensures communication between cells, organs and even organisms. Hormones, neuropeptides and antibodies, among other cargoes are packed in exocytic vesicles that need to reach and fuse with the plasma membrane to release their content to the extracellular milieu. Hundreds of proteins participate in this process and several others in its regulation. ...

    • Zonda is a novel early component of the autophagy pathway in Drosophila 

      Melani, Mariana; Valko, Ayelen; Romero, Nuria M; Aguilera, Milton O; Acevedo, Julieta M; Bhujabal, Zambarlal; Perez-Perri, Joel; De La Riva-Carrasco, Rocio V; Katz, Maximiliano J; Sorianello, Eleonora; D'Alessio, Cecilia; Juhasz, Gabor; Johansen, Terje; Colombo, Maria I; Wappner, Pablo (Journal article; Tidsskriftartikkel; Peer reviewed, 2017-09-13)
      Autophagy is an evolutionary conserved process by which eukaryotic cells undergo self-digestion of cytoplasmic components. Here we report that a novel Drosophila immunophilin, which we have named Zonda, is critically required for starvation-induced autophagy. We show that Zonda operates at early stages of the process, specifically for Vps34-mediated phosphatidylinositol 3-phosphate (PI3P) deposition. ...